Ischemic heart disease (IHD), a leading cause of mortality worldwide, is primarily caused by atherosclerosis. Currently, the pathology of IHD is still not fully understood. Decades of pharmacology research have accumulated a wealth of knowledge on genetic pathology, but conventional approaches cannot resolve tissue microstructures and cell dysfunctions1. Single-cell RNA sequencing (scRNA-seq) and spatial transcriptomics (ST) paved new roads for IHD research. However, technical limitations and inadequate sample volume still hindered understanding of cells and tissue architecture at different stages of IHD2. Furthermore, the inconsistency of experimental operations and computations between laboratories make cross-validation of different studies less reliable. In this letter, we introduced Spatial Single-cell Ischemic Heart Disease Browser (ssIHDB), a comprehensive, spatio-temporally resolved resource that integrated single-cell and spatial transcriptomes with a manually curated knowledgebase of genes, drugs, and comorbidities relevant to IHD (https://xomics.com.cn/ihdb/).